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The causes of this disease are still unknown. Starting from now widely documented to hereditary factors, genetic or otherwise, is gaining momentum among scholars a theory, yet to be confirmed, about the eziopatogenesi (the origin and mechanism Determinants disease), according to which infections type virus, activate genes involved (approximately twenty), with subsequent stimulation of the keratinocytes and manifestation of symptoms; other mechanism envisaged would lead to a destabilization of the immune system defense, which no longer able to recognize certain cells of the body, become unable to maintain the sopita latent disease. This suggests an autoimmune nature of psoriasis.
Up to now, therefore, we can not talk about real causes but to trigger factors. Consideriamone few. Emotional stress factors are considered important influence in the history of the disease. In individuals predisposed psicoemotivo any event of a major disease may worsen or even make manifest the symptoms until then sopiti. Trauma: mechanical (abrasion, scratch, injections, insect bites, tattoos and so on), physical (low temperature), chemical (Irrigative contact with substances) or otherwise, are recognized as leaders of the "phenomenon of Koebner" namely the appearance of psoriasis lesions, even at a distance of time seemingly healthy skin on. Typically, the sun and the warm climate improves psoriasis, but sometimes there is a deterioration as a result of exposure to ultraviolet rays, especially in people with photosensitive skin.
Drugs such as lithium (antidepressant), beta-blockers (antihypertensive), anti-malarials, indomethacin, salicylates, iodates compounds can act as trigger factors, while the steroids made by local or systemic can lead to acute psoriatic eruption at the time of suspension or reduction in dosage.
Hormonal factors: the appearance of psoriasis or an exacerbation were found at specific stages of life, like puberty and menopause, so forward a relationship with the course of the disease. Metabolic disorders: a state of hypocalcemia (lack of calcium in the blood) due to various causes, including dialysis, is often considered a factor in worsening of psoriasis.
Food and lifestyles, even if it has not yet been demonstrated certainly a direct relationship of alcohol and smoking with the unleashing of psoriasis, patients suffering from serious illness are often consumers of alcoholic beverages and heavy smokers, also follow a particular diet rich in animal protein.