We had already talked about acne and remedies against a cure pimples presenting innovative, Zeno; hours trying to investigate the pharmacological treatments for pimples. The acne is a skin disease characterized from an inflammation of a hair follicle and sebaceous gland attached, and pimples caused from acne occurs noso primarily on the face, but sometimes also in other districts as the body schiena. Le from acne causes are varied and different depending on the age in which manifests itself: undoubtedly adolescents component hormone plays a role. The bulk production of androgens in young induce greater sebaceous secretion, and increased activities of the glands. If this is accompanied by a lack of growth of the skin, so the sebum remains trapped in the dermis rather than escape to the surface, it may trigger an inflammatory process because of the presence (normal saline) of a bacterium, Propionibacterium acnes on, the cause the emergence of more or less pimples.
Conversely into adulthood, acne can affect primarily women, due to the fall in estrogen levels that occur in menopause, with a total similar mechanisms.
These hormonal factors are also to add environmental factors: air pollution can block the sebaceous glands, as well as poor hygiene, wet climate favors the proliferation of bacteria (in summer, exposing the skin to the sun has a total of acne reduction), similar to the use of oily cosmetics.
The acne is a disease in spontaneous healing, but it is a disease with a great social impact the psychological implications which may have important repercussions on the individual. For this reason, although most often it is not strictly necessary, you can use drugs to treat of acne always remembering that every drug can have side effects more or less serious.
The treatments available are essentially 3: antibiotic therapy, and hormonal keratolytic.
The antibiotic therapy for acne aims to eradicate Propionibacterium acnes, thereby reducing the inflammatory process which is the main cause. The drugs are given antibiotics in the treatment of mild and moderate. It seems that the antibiotics systemic are generally more effective than topical , the latter, because of their slow action, can develop bacterial resistance that their effectiveness over time is reduced to zero.
Antibiotics are the most used tetracycline and erythromycin. The first group has possible side effects such as gastrointestinal disorders (nausea, vomiting, diarrhea), any skin allergies, photo toxicity (it is essential to avoid exposure to the sun during treatment and in the days immediately following), should never be undertaken before going to read because they are a possible cause of esophageal ulcers.
The erythromycin is widely used in the treatment of acne, but has never recommended to take this drug very long, because of frequent events on gastrointestinal, in some cases can induce transient deafness.
Keratolytic therapy is based on the principle that accelerating the turn-over (the average life) cells of the skin may be removed those "plugs" that obstruct the sebaceous glands, making it more difficult to inflammation.
Drugs are used mainly as ointments, although there are also some medications to be taken orally, may be associated with antibiotics for greater effectiveness. The drugs are keratolytic derivatives of vitamin A (found in vegetable color to yellow-orange, mauve, carrots, rocket, pumpkin, spinach, khaki).
Taking these drugs should always be accompanied by a thorough cleansing of the face, to remove the peeling of the skin cell. As side effects, may cause local irritation, itching, dry skin. At the beginning of treatment, you could attend a worsening of the situation, but this is normal in the first 2-3 weeks, at the end of which the situation will improve gradually.
The hormonal therapy is justified only in patients with endocrine dysfunction and has never recommended in cases of juvenile acne. Moreover, the benefits of hormone therapy are not constant and are limited to the period of taking the drug, it should also be taken into account the possible side effects, because altering the concentration of hormones in our body, it will induce changes in other organs with consequences can be very serious.
Of particular importance, so as to merit an alert aside, is the drug Roaccutan; Roaccutan is for "serious forms of acne resistant to adequate courses of standard therapy with systemic antibacterial and topical therapy." The drug is sold on prescription and non-repeatable governed by a complex legislation, because of possible serious side effects. The mechanism of action has not yet been fully clarified, it is assumed "that the improvement observed in clinical of acne serious is associated inhibit the activity of the sebaceous glands and a reduction histologically proven the size of sebaceous glands . Also found was an anti-inflammatory effect at of Isotretinoin skin. "(From the textual description leaflet). E ‘vital signal the absolute contraindication of recruitment and mandatory pregnancy.